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KMID : 0856920150180020120
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Journal of Hospice and Palliative Care
2015 Volume.18 No. 2 p.120 ~ p.127
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Relationship between Vitamin D Level and Survival in Terminally Ill Cancer Patients
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Choi Sun-Young
Choi Youn-Seon
Hwang In-Cheol
Lee June-Young
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Abstract
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Purpose: We aimed to investigate how serum vitamin D levels are related to survival of terminally ill cancer patients.
Methods: From May 2012 through June 2013, a retrospective chart review was performed on 96 hospice patients. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with severe vitamin D deficiency and Coxcy and Coxional hazard analyses were used to evaluate effects on survival.
Results: The mean vitamin D level in patients was 8.60±7.16 ng/ml. Vitamin D was severely deficient (＜10 ng/ml) in 75 patients (78.2%), deficient (10∼20 ng/ml) in 13 patients (13.5%), relatively insufficient (21∼29 ng/ml) in five patients (8.3%) and sufficient ((t ng/ml) in three patients (3.1%). Hyperbilirubinemia (≥1.2 g/dl) was the only factor associated with severe vitamin D deficiency according to the multiple logistic regression analysis (Odds ratio, OR=18.48, P＜0.05). Although hyperbilirubinemia showed a strong association with survival (Hazard ratio, HR=2.25, P＜0.01), no association was found between severe vitamin D deficiency and survival (HR=1.15, P＞0.05) in Cox’s proportional hazard analysis.
Conclusion: Although serum vitamin D levels were severely low in terminally ill cancer patients, we found no association between severe vitamin D deficiency and patient survival.
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KEYWORD
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Vitamin D, Terminal care, Survival analysis, Hospices
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